Specific receptor sites for chemotactic peptides on human polymorphonuclear leukocytes.

@article{Williams1977SpecificRS,
  title={Specific receptor sites for chemotactic peptides on human polymorphonuclear leukocytes.},
  author={Lewis T. Williams and Ralph Snyderman and M. C. Pike and Robert J Lefkowitz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1977},
  volume={74 3},
  pages={1204-8}
}
Synthetic N-formylmethionyl peptides are chemotactic attractants for human polymorphonuclear leukocytes. The well-defined structure-activity relationship of these peptides in eliciting a chemotactic response suggests that the interaction of the peptides with a specific cellular binding site may initiate chemotaxis. By using tritiated N-formylmethionyl-leucyl-phenylalanine (fMet-Leu-[3H]Phe), a potent chemotactic peptide with high specific radioactivity, we have directly identified binding sites… CONTINUE READING

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