Specific radiation damage to acidic residues and its relation to their chemical and structural environment.

@article{Fioravanti2007SpecificRD,
  title={Specific radiation damage to acidic residues and its relation to their chemical and structural environment.},
  author={Emanuela Fioravanti and Fr{\'e}d{\'e}ric M. D. Vellieux and Patricia Amara and Dominique Madern and Martin Weik},
  journal={Journal of synchrotron radiation},
  year={2007},
  volume={14 Pt 1},
  pages={
          84-91
        }
}
Intense synchrotron radiation produces specific structural and chemical damage to crystalline proteins even at 100 K. Carboxyl groups of acidic residues (Glu, Asp) losing their definition is one of the major effects observed. Here, the susceptibilities to X-ray damage of acidic residues in tetrameric malate dehydrogenase from Haloarcula marismortui are investigated. The marked excess of acidic residues in this halophilic enzyme makes it an ideal target to determine how specific damage to acidic… CONTINUE READING
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