Specific proton pump inhibitors E3810 and lansoprazole affect the recovery process of gastric secretion in rats differently.

@article{Tomiyama1994SpecificPP,
  title={Specific proton pump inhibitors E3810 and lansoprazole affect the recovery process of gastric secretion in rats differently.},
  author={Yumiko Tomiyama and Magotoshi Morii and Noriaki Takeguchi},
  journal={Biochemical pharmacology},
  year={1994},
  volume={48 11},
  pages={2049-55}
}
After a single subcutaneous administration (30 mg/kg) of proton pump inhibitor 2-[(4-(3-methoxypropoxy)-3-methylpyridin-2-yl)-methylsulfiny l]- 1H-benzimidazole sodium salt (E3810), or lansoprazole in rats, time courses of inhibitory and recovery processes of acid secretion in vivo and pump enzyme activity in isolated microsomes were measured. The acid secretion rate which reflects H+,K(+)-ATPase activity in the secretory canalicular (apical) membrane was compared with that in the microsomal… CONTINUE READING