Specific protein-membrane contacts are required for prepore and pore assembly by a cholesterol-dependent cytolysin.

@article{Soltani2007SpecificPC,
  title={Specific protein-membrane contacts are required for prepore and pore assembly by a cholesterol-dependent cytolysin.},
  author={Casie E Soltani and Eileen M. Hotze and Arthur E. Johnson and Rodney Ko Tweten},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 21},
  pages={
          15709-16
        }
}
Three short hydrophobic loops and a conserved undecapeptide at the tip of domain 4 (D4) of the cholesterol-dependent cytolysins (CDCs) mediate the binding of the CDC monomers to cholesterol-rich cell membranes. But intermedilysin (ILY), from Streptococcus intermedius, does not bind to cholesterol-rich membranes unless they contain the human protein CD59. This observation suggested that the D4 loops, which include loops L1-L3 and the undecapeptide, of ILY were no longer required for its cell… CONTINUE READING
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