Specific protein kinase C isoforms as transducers and modulators of insulin signaling.

  title={Specific protein kinase C isoforms as transducers and modulators of insulin signaling.},
  author={Sanford R. Sampson and Denise R. Cooper},
  journal={Molecular genetics and metabolism},
  volume={89 1-2},
Recent studies implicate specific PKC isoforms in the insulin-signaling cascade. Insulin activates PKCs alpha, betaII, delta and zeta in several cell types. In addition, as will be documented in this review, certain members of the PKC family may also be activated and act upstream of PI3 and MAP kinases. Each of these isoforms has been shown one way or another either to mimic or to modify insulin-stimulated effects in one or all of the insulin-responsive tissues. Moreover, each of the isoforms… CONTINUE READING
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