Specific protection of 16 S rRNA by translational initiation factors.

  title={Specific protection of 16 S rRNA by translational initiation factors.},
  author={Danesh Moazed and Raymond R. Samaha and Claudio O. Gualerzi and Harry F. Noller},
  journal={Journal of molecular biology},
  volume={248 2},
The binding of initiation factors to 30 S ribosomal subunits protects specific sets of nucleotides in 16 S rRNA from base-specific chemical probes. Initiation factor 3 (IF-3) protects residues G700, G703 and G791 from attack by kethoxal. These protected bases are close to those in 16 S rRNA that are protected by 50 S subunits, providing a structural basis for the subunit dissociation activity of IF-3. The IF-3-dependent protections also flank bases that are protected by P-site-bound tRNA, in… CONTINUE READING
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