Specific postendocytic proteolysis of apolipoprotein B in oocytes does not abolish receptor recognition.

@article{Nimpf1989SpecificPP,
  title={Specific postendocytic proteolysis of apolipoprotein B in oocytes does not abolish receptor recognition.},
  author={Johannes Nimpf and Mirjana Radosavljevic and Wolfgang Johann Schneider},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 3},
  pages={906-10}
}
Upon receptor-mediated transfer of plasma very low density lipoprotein (VLDL) particles into growing chicken oocytes, their major apolipoprotein (apo) component, apoB, is proteolytically cleaved. apoB fragmentation appears to be catalyzed by cathepsin D or a similar pepstatin A-sensitive protease and results in the presence of a characteristic set of polypeptides on yolk VLDL particles. The nicks introduced into the apoB backbone during postendocytic processing occur in yolk platelets and… CONTINUE READING