Specific polymorphic variation in the mitochondrial genome and increased in-hospital mortality after severe trauma.

Abstract

OBJECTIVE To determine whether specific genetic variations in the mtDNA that impact energy production and free-radical generation are potential new risk factors for in-hospital mortality after severe trauma. SUMMARY BACKGROUND DATA Each of the 3 mitochondrial DNA polymorphisms selected for this study (at positions 4216, 10398, 4917) alter the amino acid… (More)

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