Specific polyclonal F(ab')2 neutralize a large panel of highly pathogenic avian influenza A viruses (H5N1) and control infection in mice.

@article{Herbreteau2014SpecificPF,
  title={Specific polyclonal F(ab')2 neutralize a large panel of highly pathogenic avian influenza A viruses (H5N1) and control infection in mice.},
  author={C{\'e}cile H Herbreteau and Fr{\'e}d{\'e}ric Jacquot and Sareth Rith and L. Vacher and Ludovic Nguyen and Caroline Carbonnelle and Vincent Lotteau and Michel Jolivet and Herv{\'e} Raoul and Philippe Buchy and Jean-François Saluzzo},
  journal={Immunotherapy},
  year={2014},
  volume={6 6},
  pages={
          699-708
        }
}
AIM There is still no specific therapy for infection with the highly pathogenic avian influenza A virus (HPAI) H5N1, which caused 39 human cases with a 64% fatality rate in 2013. MATERIALS & METHODS We prepared highly purified specific equine polyclonal immunoglobulin fragments (F(ab')2) against H5N1 and tested them for efficacy in vitro and with different administration schedules in H5N1-challenged BALB/c mice. RESULTS in vitro, F(ab')2 neutralized 21 different H5N1 strains from different… CONTINUE READING
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