Specific physiological roles of cytosolic phospholipase A(2) as defined by gene knockouts.

@article{Sapirstein2000SpecificPR,
  title={Specific physiological roles of cytosolic phospholipase A(2) as defined by gene knockouts.},
  author={Adam Sapirstein and Joseph V. Bonventre},
  journal={Biochimica et biophysica acta},
  year={2000},
  volume={1488 1-2},
  pages={139-48}
}
The cytosolic 85 kDa phospholipase A(2) (cPLA(2)) is a unique member of the phospholipase A(2) (PLA(2)) superfamily. Because PLA(2) activity and eicosanoid production are important in normal and pathophysiological states we and the laboratory of Shimizu created a mouse deficient in cPLA(2) (cPLA(2)(-/-) mouse). cPLA(2)(-/-) mice develop normally but the females have severe reproductive defects. cPLA(2)(-/-) mice suffer smaller infarcts and fewer neurological deficits after transient occlusion… CONTINUE READING
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