Specific phosphorylation of SR proteins by mammalian DNA topoisomerase I

@article{Rossi1996SpecificPO,
  title={Specific phosphorylation of SR proteins by mammalian DNA topoisomerase I},
  author={Ferdinand Rossi and Emmanuel Labourier and Thierry Forn{\'e} and Gilles Divita and Jean Derancourt and Jean François Riou and Etienne Antoine and G. Cathala and Claude Brunel and Jamal Tazi},
  journal={Nature},
  year={1996},
  volume={381},
  pages={80-82}
}
SEVERAL metazoan splicing factors are characterized by ribo-nucleoprotein (RNP) consensus sequences and arginine–serine repeats (RS domain)1–8 which are essential for their function in splicing5,9,10. These include members of the SR-protein family (SC35, SF2/ASF), the U1 small nuclear (sn)RNP protein (U1-70K) and the U2 snRNP auxiliary factor (U2AF). SR proteins are phosphorylated in vivo11 and the phosphorylation state of U1-70K's RS domain influences its splicing activity12. Here we report… CONTINUE READING