Specific penetration and accumulation of a homing peptide within atherosclerotic plaques of apolipoprotein E-deficient mice.

Abstract

The ability to selectively deliver compounds into atherosclerotic plaques would greatly benefit the detection and treatment of atherosclerotic disease. We describe such a delivery system based on a 9-amino acid cyclic peptide, LyP-1. LyP-1 was originally identified as a tumor-homing peptide that specifically recognizes tumor cells, tumor lymphatics, and… (More)
DOI: 10.1073/pnas.1104540108

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Cite this paper

@article{Hamzah2011SpecificPA, title={Specific penetration and accumulation of a homing peptide within atherosclerotic plaques of apolipoprotein E-deficient mice.}, author={Juliana Hamzah and Venkata Ramana Kotamraju and Jai Woong Seo and Lilach Agemy and Valentina Fogal and Lisa M. Mahakian and David G. Peters and Lise Roth and M. Karen J. Gagnon and Katherine W. Ferrara and Erkki Ruoslahti}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2011}, volume={108 17}, pages={7154-9} }