Specific pattern of RAS oncogene mutations in follicular thyroid tumors.

  title={Specific pattern of RAS oncogene mutations in follicular thyroid tumors.},
  author={Vasily V Vasko and Mireille Ferrand and Julie Di Cristofaro and Pierre Carayon and Jean François Henry and Catherine De Micco},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={88 6},
The prevalence of H-RAS, K-RAS, and N-RAS gene mutations in thyroid tumors according to malignancy and histology is controversial. Differences in methodology and histological classifications may explain discrepant results. To address this issue, we first performed a pooled analysis of 269 mutations garnered from 39 previous studies. Mutations proved significantly less frequent when detected with direct sequencing than without (12.3% vs. 17%). The rate of mutation involving N-RAS exon 1 (N1) and… CONTINUE READING
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