Specific nucleoprotein residues affect influenza virus morphology.

@article{Bialas2014SpecificNR,
  title={Specific nucleoprotein residues affect influenza virus morphology.},
  author={Kristy M. Bialas and Kendra A Bussey and Raychel L Stone and Toru Takimoto},
  journal={Journal of virology},
  year={2014},
  volume={88 4},
  pages={2227-34}
}
Influenza virus strains are often pleiomorphic, a characteristic that is largely attributed to specific residues in matrix protein 1 (M1). Although the mechanism by which M1 controls virion morphology has not yet been defined, it is suggested that the M1 interaction with other viral proteins plays an important role. In this study, we rescued recombinant virus WSN-AichiM1 containing the spherical A/WSN/33 (WSN) backbone and the M1 protein from A/Aichi/2/68 (Aichi). Aichi M1 differs from WSN M1… CONTINUE READING
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