Specific mutations of hepatitis B virus in plasma predict liver cancer development.

@article{Kuang2004SpecificMO,
  title={Specific mutations of hepatitis B virus in plasma predict liver cancer development.},
  author={Shuang-Yuan Kuang and P. Jackson and J. Wang and P. Lu and A. Muňoz and G. Qian and T. Kensler and J. Groopman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 10},
  pages={
          3575-80
        }
}
  • Shuang-Yuan Kuang, P. Jackson, +5 authors J. Groopman
  • Published 2004
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences of the United States of America
  • A major risk factor for hepatocellular carcinoma (HCC) is hepatitis B virus (HBV), whose pathogenesis is exacerbated by the acquisition of mutations that accelerate carcinogenesis. We examined, with mass spectrometry, the temporality of an HBV 1762(T)/1764(A) double mutation in plasma and tumors. Initial studies found that 52 of 70 (74.3%) tumors from patients residing in Qidong, People's Republic of China, contained this HBV mutation. Paired plasma samples were available for six of the tumor… CONTINUE READING
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    Hepatitis B virus-induced oncogenesis.
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    HBV induced carcinogenesis.
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