Specific mutations of hepatitis B virus in plasma predict liver cancer development.

@article{Kuang2004SpecificMO,
  title={Specific mutations of hepatitis B virus in plasma predict liver cancer development.},
  author={S H Kuang and Peta E. Jackson and Jin-bing Wang and Pei-Xing Lu and Alvaro Muňoz and Geng-sun Qian and Thomas Wells Kensler and John D. Groopman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 10},
  pages={3575-80}
}
A major risk factor for hepatocellular carcinoma (HCC) is hepatitis B virus (HBV), whose pathogenesis is exacerbated by the acquisition of mutations that accelerate carcinogenesis. We examined, with mass spectrometry, the temporality of an HBV 1762(T)/1764(A) double mutation in plasma and tumors. Initial studies found that 52 of 70 (74.3%) tumors from patients residing in Qidong, People's Republic of China, contained this HBV mutation. Paired plasma samples were available for six of the tumor… CONTINUE READING
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