Specific monosynaptic sensory-motor connections form in the absence of patterned neural activity and motoneuronal cell death.

@article{Mendelson1991SpecificMS,
  title={Specific monosynaptic sensory-motor connections form in the absence of patterned neural activity and motoneuronal cell death.},
  author={Bilha Mendelson and Eric Frank},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1991},
  volume={11 5},
  pages={1390-403}
}
The importance of neural activity and motoneuronal cell death in the formation of specific synaptic connections between muscle afferents and motoneurons was studied in chick embryos. Patterned neural activity was blocked by applying d-tubocurarine (dtc) chronically to embryos during the period when sensory-motor connections are formed [stages (St) 28-42]. Dtc blocks neurogenic muscle contractions, thereby abolishing any temporal correlation between neural activity in motoneurons and stretch… CONTINUE READING