Specific monoclonal antibodies against IDH1/2 mutations as diagnostic tools for gliomas

  title={Specific monoclonal antibodies against IDH1/2 mutations as diagnostic tools for gliomas},
  author={Yukinari Kato},
  journal={Brain Tumor Pathology},
Mutations of isocitrate dehydrogenase 1/2 (IDH1/2) have been reported in gliomas and other types of tumors, such as acute myeloid leukemias, cartilaginous tumors, intrahepatic cholangiocarcinomas, osteosarcomas, and giant cell tumors of bone. In gliomas, IDH mutations uniformly occur in the functionally critical arginine 132 residue (R132) of IDH1 and arginine 172 residue (R172) of IDH2. IDH1 and IDH2 catalyze the oxidative carboxylation of isocitrate to α-ketoglutarate (α-KG) in the cytosol… CONTINUE READING


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