Specific metabolites in the medial prefrontal cortex are associated with the neurocognitive deficits in schizophrenia: A preliminary study

@article{Shirayama2010SpecificMI,
  title={Specific metabolites in the medial prefrontal cortex are associated with the neurocognitive deficits in schizophrenia: A preliminary study},
  author={Yukihiko Shirayama and Takayuki Obata and Daisuke Matsuzawa and Hiroi Nonaka and Yoko Kanazawa and Eiji Yoshitome and Hiroo Ikehira and Kenji Hashimoto and Masaomi Iyo},
  journal={NeuroImage},
  year={2010},
  volume={49},
  pages={2783-2790}
}
We measured brain metabolites in the medial prefrontal cortex of 19 schizophrenic patients and 18 healthy controls by 3 T proton magnetic resonance spectroscopy ((1)H MRS), and examined the relationship between prefrontal cortex-related neurocognitive functions and brain metabolites in the medial prefrontal cortex. The patients with schizophrenia exhibited deficits on the verbal fluency, Wisconsin card sorting test (WCST), trail making test, Stroop test and digit span distraction test (DSDT… CONTINUE READING

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