Specific maternal microchimeric T cells targeting fetal antigens in β cells predispose to auto-immune diabetes in the child.

@article{Roy2011SpecificMM,
  title={Specific maternal microchimeric T cells targeting fetal antigens in β cells predispose to auto-immune diabetes in the child.},
  author={Edwige Roy and Mich{\`e}le Leduc and Sarah Gu{\'e}gan and Latif Rachdi and Nicolas Kluger and Rapha{\"e}l Scharfmann and S{\'e}lim Aractingi and Kiarash Khosrotehrani},
  journal={Journal of autoimmunity},
  year={2011},
  volume={36 3-4},
  pages={253-62}
}
OBJECTIVE During pregnancy there is an exchange of cells between the fetus and the mother including T lymphocytes that can persist after delivery. Previous studies have described an increased numbers of maternal cells in children with juvenile diabetes as compared to their unaffected siblings. Our objective was to assess the possibility for these chimeric T cells to trigger an anti-beta cell response. RESEARCH DESIGN AND METHODS We mated OT2 transgenic female mice having T cells specifically… CONTINUE READING

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