Specific lymphoproliferation, gamma interferon production, and serum immunoglobulin G directed against a purified 32 kDa mycobacterial protein antigen (P32) in patients with active tuberculosis.

@article{Huygen1988SpecificLG,
  title={Specific lymphoproliferation, gamma interferon production, and serum immunoglobulin G directed against a purified 32 kDa mycobacterial protein antigen (P32) in patients with active tuberculosis.},
  author={Kris Huygen and J-P Van Vooren and Mireille Turneer and Robert Bosmans and Paul Dierckx and Jean-Marc De Bruyn},
  journal={Scandinavian journal of immunology},
  year={1988},
  volume={27 2},
  pages={187-94}
}
Twenty-one patients treated for active tuberculosis were examined for immune reactivity to purified protein derivative (PPD) and to a purified 32-kDa protein antigen (P32) from Mycobacterium bovis, strain BCG. Lymphoproliferation of peripheral blood leucocytes to PPD and P32 was positive in 95% and 71% of the patients respectively. A positive IFN-gamma response was detected in 62% against PPD and in 48% against P32. Low blastogenesis and IFN-gamma production were observed, especially in… CONTINUE READING

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