Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant.

@article{Rowan1996SpecificLO,
  title={Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant.},
  author={Sheldon Rowan and Robert L. Ludwig and Ygal Haupt and Stewart Bates and Xiaoling Lu and Moshe Oren and Karen Heather Vousden},
  journal={The EMBO journal},
  year={1996},
  volume={15 4},
  pages={827-38}
}
The p53 tumor-suppressor gene product is frequently inactivated in malignancies by point mutation. Although most tumor-derived p53 mutants show loss of sequence specific transcriptional activation, some mutants have been identified which retain this activity. One such mutant, p53175P, is defective for the suppression of transformation in rodent cells, despite retaining the ability to suppress the growth of p53-null human cells. We now demonstrate that p53175P can induce a cell-cycle arrest in… CONTINUE READING

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