Specific lentiviral shRNA-mediated knockdown of cyclin D1 in mantle cell lymphoma has minimal effects on cell survival and reveals a regulatory circuit with cyclin D2

@article{Klier2008SpecificLS,
  title={Specific lentiviral shRNA-mediated knockdown of cyclin D1 in mantle cell lymphoma has minimal effects on cell survival and reveals a regulatory circuit with cyclin D2},
  author={Margit Klier and Nata{\vs}a Anastasov and Andreas Hermann and Thomas Meindl and Daniela Angermeier and Mark A. Raffeld and Falko Fend and Leticia Quintanilla-Martinez},
  journal={Leukemia},
  year={2008},
  volume={22},
  pages={2097-2105}
}
Cyclin D1 overexpression is the hallmark of mantle cell lymphoma (MCL). However, the importance of cyclin D1 in the maintenance and progression of the disease remains to be defined. The aim of this study was to elucidate the role of cyclin D1 overexpression using an efficient cyclin D1-shRNA and a lentiviral system in well-characterized MCL cell lines. Surprisingly, the knockdown of cyclin D1 led to a moderate retardation in growth, without induction of apoptosis. The cyclin D1-shRNA-transduced… CONTINUE READING
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mRNA levels in cases

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