Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

@article{Bryant2005SpecificKO,
  title={Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase},
  author={Helen E. Bryant and N. Schultz and Huw D. Thomas and Kayan M. Parker and D. Flower and Elena Lopez and S. Kyle and M. Meuth and Nicola J. Curtin and T. Helleday},
  journal={Nature},
  year={2005},
  volume={434},
  pages={913-917}
}
  • Helen E. Bryant, N. Schultz, +7 authors T. Helleday
  • Published 2005
  • Medicine, Chemistry
  • Nature
  • Poly(ADP-ribose) polymerase (PARP1) facilitates DNA repair by binding to DNA breaks and attracting DNA repair proteins to the site of damage. Nevertheless, PARP1-/- mice are viable, fertile and do not develop early onset tumours. Here, we show that PARP inhibitors trigger γ-H2AX and RAD51 foci formation. We propose that, in the absence of PARP1, spontaneous single-strand breaks collapse replication forks and trigger homologous recombination for repair. Furthermore, we show that BRCA2-deficient… CONTINUE READING

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