Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol.

@article{Cogram2004SpecificIO,
  title={Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol.},
  author={P Cogram and Andrew Hynes and Louisa P E Dunlevy and Nicholas D. E. Greene and Andrew J Copp},
  journal={Human molecular genetics},
  year={2004},
  volume={13 1},
  pages={7-14}
}
A proportion of neural tube defects (NTDs) can be prevented by maternal folic acid supplementation, although some cases are unresponsive. The curly tail mutant mouse provides a model of folate-resistant NTDs, in which defects can be prevented by inositol therapy in early pregnancy. Hence, inositol represents a possible novel adjunct therapy to prevent human NTDs. The present study investigated the molecular mechanism by which inositol prevents mouse NTDs. Activation of protein kinase C (PKC) is… CONTINUE READING
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Folate and Human Development

  • N.D.E. Greene, A. J. Copp
  • Humana Press Inc,
  • 2002

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