Specific involvement of atypical PKCζ/PKMζ in spinal persistent nociceptive processing following peripheral inflammation in rat

@inproceedings{Marchand2011SpecificIO,
  title={Specific involvement of atypical PKCζ/PKMζ in spinal persistent nociceptive processing following peripheral inflammation in rat},
  author={Fabien Marchand and Richard G D'mello and Ping Kei Yip and Margarita Calvo and Emilie Muller and Sophie Pezet and Anthony Henry Dickenson and Stephen B. McMahon},
  booktitle={Molecular pain},
  year={2011}
}
BACKGROUND Central sensitization requires the activation of various intracellular signalling pathways within spinal dorsal horn neurons, leading to a lowering of activation threshold and enhanced responsiveness of these cells. Such plasticity contributes to the manifestation of chronic pain states and displays a number of features of long-term potentiation (LTP), a ubiquitous neuronal mechanism of increased synaptic strength. Here we describe the role of a novel pathway involving atypical PKC… CONTINUE READING
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