Specific involvement of SRC family kinase activation in the pathogenesis of retinal neovascularization.

@article{Werdich2006SpecificIO,
  title={Specific involvement of SRC family kinase activation in the pathogenesis of retinal neovascularization.},
  author={Xiang Q. Werdich and John S. Penn},
  journal={Investigative ophthalmology & visual science},
  year={2006},
  volume={47 11},
  pages={5047-56}
}
PURPOSE Src family kinases (SFKs) are membrane-attached nonreceptor protein tyrosine kinases that link a variety of extracellular cues to intracellular signal pathways. The purpose of this study was to characterize the roles of SFKs in vascular endothelial growth factor (VEGF)-mediated retinal angiogenesis. METHODS Primary rat retinal glial Müller cells and bovine and human retinal microvascular endothelial cells (RMECs) were used in the in vitro studies. A rat model of retinopathy of… CONTINUE READING