Specific interferon genes are expressed in individual cells in the peritoneum and bone marrow of normal mice.

@article{Proietti1992SpecificIG,
  title={Specific interferon genes are expressed in individual cells in the peritoneum and bone marrow of normal mice.},
  author={Enricos Proietti and Caroline Vanden Broecke and Paola Di Marzio and Sandra Gessani and Ion Gresser and Michael G Tovey},
  journal={Journal of interferon research},
  year={1992},
  volume={12 1},
  pages={27-34}
}
The use of a highly sensitive method of in situ hybridization capable of detecting one copy of IFN mRNA per cell showed that from 20-50% of the cells from the peritoneum and bone marrow of both normal pathogen-free and axenic mice exhibited grain counts significantly greater than background levels following hybridization with riboprobes specific for the mouse interferon-alpha (IFN-alpha), IFN-beta, or IFN-gamma genes. Labeling was shown to be specific, as the labeled probe was displaced by a… CONTINUE READING