Specific interactions between the Candida albicans ABC transporter Cdr1p ectodomain and a D-octapeptide derivative inhibitor.

Abstract

Overexpression of the Candida albicans ATP-binding cassette transporter CaCdr1p causes clinically significant resistance to azole drugs including fluconazole (FLC). Screening of a ~1.89 × 10(6) member D-octapeptide combinatorial library that concentrates library members at the yeast cell surface identified RC21v3, a 4-methoxy-2,3,6-trimethylbenzenesulphonyl… (More)
DOI: 10.1111/j.1365-2958.2012.08140.x

Cite this paper

@article{Niimi2012SpecificIB, title={Specific interactions between the Candida albicans ABC transporter Cdr1p ectodomain and a D-octapeptide derivative inhibitor.}, author={Kyoko Niimi and David R K Harding and Ann R Holmes and Erwin Lamping and Masakazu Niimi and Joel D A Tyndall and Richard D Cannon and Brian C Monk}, journal={Molecular microbiology}, year={2012}, volume={85 4}, pages={747-67} }