Specific interaction between the XNP/ATR-X gene product and the SET domain of the human EZH2 protein.

@article{Cardoso1998SpecificIB,
  title={Specific interaction between the XNP/ATR-X gene product and the SET domain of the human EZH2 protein.},
  author={Carlos Cardoso and Serge Timsit and Laurent Villard and Michel Khrestchatisky and Michel Font{\'e}s and Laurence Colleaux},
  journal={Human molecular genetics},
  year={1998},
  volume={7 4},
  pages={
          679-84
        }
}
Mutations in the XNP gene result in different inherited disorders, including the ATR-X syndrome which is characterized by mental retardation (MR) associated with alpha-thalaessemia. Amino acid sequence analysis revealed that the XNP protein is a new member of the SNF2-like family, which comprises numerous members involved in a broad range of biological functions: transcriptional regulation, DNA repair and chromosome segregation. Since experiments on fibroblasts from ATR-X patients have provided… CONTINUE READING
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