Specific interaction between a novel enediyne chromophore and apoprotein in macromolecular antitumor antibiotic C-1027.

@article{Matsumoto1993SpecificIB,
  title={Specific interaction between a novel enediyne chromophore and apoprotein in macromolecular antitumor antibiotic C-1027.},
  author={Tatsuya Matsumoto and Yukiko Okuno and Yuki Sugiura},
  journal={Biochemical and biophysical research communications},
  year={1993},
  volume={195 2},
  pages={
          659-66
        }
}
  • Tatsuya Matsumoto, Yukiko Okuno, Yuki Sugiura
  • Published in
    Biochemical and biophysical…
    1993
  • Chemistry, Medicine
  • The DNA cleavage experiments show that C-1027 chromophore is selectively incorporated into C-1027 apoprotein and is strongly protected by the apoprotein from loss of its DNA cleaving activity. Fluorescence and circular dichroism spectra reveal (1) important participation of tertiary structure of C-1027 apoprotein for the chromophore binding, (2) specific 1:1 binding of C-1027 chromophore to the apoprotein, and (3) significant interaction of the benzoxazine group in the chromophore-apoprotein… CONTINUE READING

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