Specific insulin binding site on T and B lymphocytes as a marker of cell activation

@article{Helderman1978SpecificIB,
  title={Specific insulin binding site on T and B lymphocytes as a marker of cell activation},
  author={J. Harold Helderman and Terry B. Strom},
  journal={Nature},
  year={1978},
  volume={274},
  pages={62-63}
}
ATTEMPTS to identify an easily measured cell surface marker that would detect activation of T or B lymphocytes in a variety of species have been unsuccessful. Although insulin receptors have been identified for fat, liver, skeletal and cardiac muscle, fibroblasts and monocytes1–8, quiescent rat splenic T lymphocytes do not bear such receptors. However, insulin receptors do emerge on T lymphocytes after concanavalin A treatment or allogeneic skin grafting9,10. Following our work on… CONTINUE READING

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