Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate.

@article{McKercher2004SpecificIO,
  title={Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate.},
  author={Ginette McKercher and Pierre L. Beaulieu and Daniel Lamarre and Steven R LaPlante and Sylvain Lef{\`e}bvre and Charles Pellerin and Louise Thauvette and George Kukolj},
  journal={Nucleic acids research},
  year={2004},
  volume={32 2},
  pages={422-31}
}
The interaction of the hepatitis C virus (HCV) RNA-dependent RNA polymerase with RNA substrate is incompletely defined. We have characterized the activities of the HCV NS5B polymerase, modified by different deletions and affinity tags, with a routinely used homopolymeric substrate, and established apparent affinities of the various NS5B constructs both for the NTP and the template/primer substrates. We identified a uniquely tagged HCV NS5B RNA polymerase construct with a lower affinity (higher… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 49 references

Diketoacid-Derivatives as Inhibitors of Polymerases

  • S. Altamura, L. Tomei, U. Koch, P.J.S. Neuner, V. Summa
  • Patent US 6492423
  • 2000
Highly Influential
4 Excerpts

A practical Oxoneâmediated, high-throughput, solution-phase synthesis of benzimidazoles from 1,2-phenylenediamines and aldehydes and its application to preparative scale synthesis

  • P. L. Beaulieu, B. HacheÂ, E. von Moos
  • Synthesis,
  • 2003

Similar Papers

Loading similar papers…