Specific inhibitors distinguish the chloride channel and drug transporter functions associated with the human multidrug resistance P-glycoprotein.

@article{Mintenig1993SpecificID,
  title={Specific inhibitors distinguish the chloride channel and drug transporter functions associated with the human multidrug resistance P-glycoprotein.},
  author={Gerard M. Mintenig and Miguel A. Lopez Valverde and Francisco V Sep{\'u}lveda and Deborah Rebecca Gill and Stephen Charles Hyde and Judy Kirk and Christopher F. Higgins},
  journal={Receptors & channels},
  year={1993},
  volume={1 4},
  pages={
          305-13
        }
}
Expression of the human multidrug resistance P-glycoprotein is associated with two activities, active drug transport and a volume-regulated chloride channel. In this study we define four classes of compound, based on their differential effects on these two activities. Class I compounds are substrates transported by P-glycoprotein. They also prevent channel activation when added to the cytoplasmic face of the membrane. Class II compounds include reversers of multidrug resistance such as… CONTINUE READING

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