Specific inhibition of the eubacterial DNA ligase by arylamino compounds.

  title={Specific inhibition of the eubacterial DNA ligase by arylamino compounds.},
  author={Giovanni Ciarrocchi and Donald G. Macphee and Leslie W Deady and Leann Tilley},
  journal={Antimicrobial agents and chemotherapy},
  volume={43 11},
All known DNA ligases catalyze the formation of a phosphodiester linkage between adjacent termini in double-stranded DNA via very similar mechanisms. The ligase family can, however, be divided into two classes: eubacterial ligases, which require NAD(+) as a cofactor, and other ligases, from viruses, archaea, and eukaryotes, which use ATP. Drugs that discriminate between DNA ligases from different sources may have antieubacterial activity. We now report that a group of arylamino compounds… CONTINUE READING

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