Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum.

@article{Amori2009SpecificIO,
  title={Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum.},
  author={Laura Amori and H Q Wu and Maura Marinozzi and Roberto Pellicciari and Paolo Guidetti and Robert M. Schwarcz},
  journal={Neuroscience},
  year={2009},
  volume={159 1},
  pages={196-203}
}
Fluctuations in the endogenous levels of kynurenic acid (KYNA), a potent alpha7 nicotinic and NMDA receptor antagonist, affect extracellular dopamine (DA) concentrations in the rat brain. Moreover, reductions in KYNA levels increase the vulnerability of striatal neurons to NMDA receptor-mediated excitotoxic insults. We now assessed the role of a key KYNA-synthesizing enzyme, kynurenine aminotransferase II (KAT II), in these processes in the rodent striatum, using KAT II KO mice-which have… CONTINUE READING
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