Specific inhibition of hepatitis C virus replication by cyclosporin A.

  title={Specific inhibition of hepatitis C virus replication by cyclosporin A.},
  author={Mina Nakagawa and Naoya Sakamoto and Nobuyuki Enomoto and Yoko Tanabe and Nobuhiko Kanazawa and Tomoyuki Koyama and Masayuki Kurosaki and Shinya Maekawa and Tsuyoshi Yamashiro and Cheng Hsin Chen and Yasuhiro Itsui and Sei Kakinuma and Mamoru Watanabe},
  journal={Biochemical and biophysical research communications},
  volume={313 1},
The difficulty in eradicating hepatitis C virus (HCV) infection is attributable to the limited treatment options against the virus. Recently, cyclosporin A (CsA), a widely used immunosuppressive drug, has been reported to be effective against HCV infection [J. Gastroenterol. 38 (2003) 567], although little is understood about the mechanism of its action against HCV. In this study, we investigated the anti-viral effects of CsA using an HCV replicon system. Human hepatoma Huh7 cells were… CONTINUE READING
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