Specific inhibition of cyclooxygenase-2 results in inhibition of proliferation of oral cancer cell lines via suppression of prostaglandin E2 production.

@article{Sumitani2001SpecificIO,
  title={Specific inhibition of cyclooxygenase-2 results in inhibition of proliferation of oral cancer cell lines via suppression of prostaglandin E2 production.},
  author={Kuniko Sumitani and Ryutaro Kamijo and Takahiko Toyoshima and Yoichi Nakanishi and Kaori Takizawa and Masashi Hatori and Masao Nagumo},
  journal={Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology},
  year={2001},
  volume={30 1},
  pages={
          41-7
        }
}
Prostaglandins (PGs) are known to play important roles in the proliferation of various types of cancer cells. PGs are produced by the action of cyclooxygenase (COX) enzymes, and two forms of COX, COX-1 and COX-2, have been described. Previous studies have demonstrated that overexpression of COX-2 is associated with colon carcinogenesis, tumor invasion and metastatic potential of colon cancer. In this study, the role of COX-2 on proliferation of squamous cell carcinoma cell lines was… CONTINUE READING
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