Specific inhibition of cyclooxygenase 2 restores antitumor reactivity by altering the balance of IL-10 and IL-12 synthesis.

@article{Stolina2000SpecificIO,
  title={Specific inhibition of cyclooxygenase 2 restores antitumor reactivity by altering the balance of IL-10 and IL-12 synthesis.},
  author={Marina Stolina and Sherven P Sharma and Ying Lin and Mariam M. Dohadwala and Brian C Gardner and Jie Luo and Li Xin Zhu and Mitchell Kronenberg and Patrice W. Miller and Joseph P. Portanova and John Cho Lee and Steven Dubinett},
  journal={Journal of immunology},
  year={2000},
  volume={164 1},
  pages={
          361-70
        }
}
Cyclooxygenase-2 (COX-2), the enzyme at the rate-limiting step of prostanoid production, has been found to be overexpressed in human lung cancer. To evaluate lung tumor COX-2 modulation of antitumor immunity, we studied the antitumor effect of specific genetic or pharmacological inhibition of COX-2 in a murine Lewis lung carcinoma (3LL) model. Inhibition of COX-2 led to marked lymphocytic infiltration of the tumor and reduced tumor growth. Treatment of mice with anti-PGE2 mAb replicated the… CONTINUE READING
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