Specific inhibition of coxsackievirus B3 translation and replication by phosphorothioate antisense oligodeoxynucleotides.

@article{Wang2001SpecificIO,
  title={Specific inhibition of coxsackievirus B3 translation and replication by phosphorothioate antisense oligodeoxynucleotides.},
  author={Aiming Wang and Paul Kim-Ming Cheung and H uifang Zhang and Christopher M. Carthy and Lubos Bohunek and Janet E. Wilson and Bruce McManus and Decheng Yang},
  journal={Antimicrobial agents and chemotherapy},
  year={2001},
  volume={45 4},
  pages={1043-52}
}
The 5' and 3' untranslated regions (UTRs) of coxsackievirus B3 (CVB3) RNA form highly ordered secondary structures that have been confirmed to play important regulatory roles in viral cap-independent internal translation initiation and RNA replication. We previously demonstrated that deletions in different regions of the 5' UTR significantly reduced viral RNA translation and infectivity. Such observations suggested strongly that viral RNA translation and replication could be blocked if highly… CONTINUE READING