Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides.

@article{Enan1992SpecificIO,
  title={Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides.},
  author={Essam Enan and Fumio Matsumura},
  journal={Biochemical pharmacology},
  year={1992},
  volume={43 8},
  pages={1777-84}
}
The inhibitory action of synthetic pyrethroids and some chlorinated hydrocarbon insecticides on the neural calcium-calmodulin-dependent protein phosphatase, calcineurin, was studied using one radiotracer and two colorimetric methods. It was found that all insecticidal Type II pyrethroids (cypermethrin, deltamethrin and fenvalerate) are potent inhibitors of isolated calcineurin from bovine brain. Their IC50 values were approximately 10(-9) to 10(-11) M. By contrast, neither noninsecticidal… CONTINUE READING
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