Specific inhibition of DNMT1/CFP1 reduces cancer phenotypes and enhances chemotherapy effectiveness.

Abstract

AIM DNA methylation is a fundamental biologic process of genomes and is a candidate for pharmacological manipulation that might have important therapeutic advantages. Thus, DNA methyltransferases (DNMTs) appear to be ideal targets for drug intervention. MATERIALS & METHODS To develop a new generation of DNMT inhibitor, we analyzed the ability of peptides to selectively inhibit certain DNMT1-incuding complexes. RESULTS Our study demonstrates that the disruption of DNMT1/CFP1-including complexes increases the efficiency of chemotherapeutic treatment on established tumors in mice. CONCLUSION Our data opens a promising and innovative alternative to the development of DNMT inhibitors.

DOI: 10.2217/epi.14.18

Cite this paper

@article{Cheray2014SpecificIO, title={Specific inhibition of DNMT1/CFP1 reduces cancer phenotypes and enhances chemotherapy effectiveness.}, author={Mathilde Cheray and Arulraj Nadaradjane and Pascal Bonnet and Sylvain Routier and François Marie Vallette and P . Cartron}, journal={Epigenomics}, year={2014}, volume={6 3}, pages={267-75} }