Specific inhibition of AQP1 water channels in human pulmonary microvascular endothelial cells by small interfering RNAs.

Abstract

BACKGROUND Aquaporin (AQP)-1 is expressed in most microvasculature endothelial cells forming water channels that play major roles in a variety of physiologic processes. Our aim was to investigate the regulatory functions of AQP1 on trancellular and paracellular permeability. METHODS We designed, synthesized, and used small interfering RNAs (siRNAs… (More)
DOI: 10.1097/TA.0b013e318230e25d

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