Specific inhibition of AKT2 by RNA interference results in reduction of ovarian cancer cell proliferation: increased expression of AKT in advanced ovarian cancer.

@article{Noske2007SpecificIO,
  title={Specific inhibition of AKT2 by RNA interference results in reduction of ovarian cancer cell proliferation: increased expression of AKT in advanced ovarian cancer.},
  author={Aurelia Noske and Alexander Kaszubiak and Wilko Weichert and Christine Sers and Silvia Niesporek and Ines Koch and Birgit Med Schaefer and Jalid Sehouli and Manfred Dietel and Herman Lage and Carsten Denkert},
  journal={Cancer letters},
  year={2007},
  volume={246 1-2},
  pages={
          190-200
        }
}
The protein kinase AKT is involved in several signaling pathways that are important for tumor development and progression, suggesting that AKT might be an interesting target for a molecular tumor therapy. In this study, we investigated the AKT expression in ovarian carcinomas and the role of the AKT isoforms to ovarian cancer cell proliferation. We observed an increased AKT expression in 58% of the primary ovarian carcinomas as compared to normal ovaries by immunohistochemistry. AKT expression… CONTINUE READING
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