Specific impairment of "what-where-when" episodic-like memory in experimental models of temporal lobe epilepsy.

@article{Inostroza2013SpecificIO,
  title={Specific impairment of "what-where-when" episodic-like memory in experimental models of temporal lobe epilepsy.},
  author={Marion Inostroza and Jorge R. Brotons-Mas and François Laurent and Elena Cid and Liset Menendez de la Prida},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 45},
  pages={17749-62}
}
Episodic memory deficit is a common cognitive disorder in human temporal lobe epilepsy (TLE). However, no animal model of TLE has been shown to specifically replicate this cognitive dysfunction, which has limited its translational appeal. Here, using a task that tests for nonverbal correlates of episodic-like memory in rats, we show that kainate-treated TLE rats exhibit a selective impairment of the "what-where-when" memory while preserving other forms of hippocampal-dependent memories… CONTINUE READING