Specific immunoreactivity of hybridoma-secreted monoclonal anti-melanoma antibodies to cultured cells and freshly derived human cells.

@article{Herlyn1980SpecificIO,
  title={Specific immunoreactivity of hybridoma-secreted monoclonal anti-melanoma antibodies to cultured cells and freshly derived human cells.},
  author={M Herlyn and W H Clark and M J Mastrangelo and Dupont Guerry and D E Elder and D LaRossa and R Hamilton and E Bondi and R Tuthill and Z Steplewski and H Koprowski},
  journal={Cancer research},
  year={1980},
  volume={40 10},
  pages={3602-9}
}
  • M Herlyn, W H Clark, +8 authors H Koprowski
  • Published 1980 in Cancer research
The specificities of monoclonal antibodies against melanoma cells were analyzed using radioimmunoassay, mixed-hemadsorption assay, and quantitative absorption on a variety of malignant and nonmalignant cells. Three of the six hybridoma-secreted antibodies bound to the majority of melanoma cell lines, melanoma tumors, and astrocytoma cell lines as well as to all normal and Epstein-Barr virus-transformed lymphocytes tested. The binding pattern coincides with the presence or absence of the DR… CONTINUE READING