Specific immunomodulatory and secretory activities of stevioside and steviol in intestinal cells.

@article{Boonkaewwan2008SpecificIA,
  title={Specific immunomodulatory and secretory activities of stevioside and steviol in intestinal cells.},
  author={Chaiwat Boonkaewwan and Mei Ao and Chaivat Toskulkao and Mrinalini Chatta Rao},
  journal={Journal of agricultural and food chemistry},
  year={2008},
  volume={56 10},
  pages={
          3777-84
        }
}
Stevioside, isolated from Stevia rebaudiana, is a commercial sweetener. It was previously demonstrated that stevioside attenuates NF-kappaB-dependent TNF-alpha and IL-1beta synthesis in LPS-stimulated monocytes. The present study examined the effects of stevioside and its metabolite, steviol, on human colon carcinoma cell lines. High concentrations of stevioside (2-5 mM) and steviol (0.2-0.8 mM) decreased cell viability in T84, Caco-2, and HT29 cells. Stevioside (2 mM) potentiated TNF-alpha… CONTINUE READING
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