Specific immune responses restored by alteration in carbohydrate chains of surface molecules on antigen-presenting cells.

@article{Boog1989SpecificIR,
  title={Specific immune responses restored by alteration in carbohydrate chains of surface molecules on antigen-presenting cells.},
  author={Claire J. P. Boog and Jacques Neefjes and Jolande Boes and Hidde L. Ploegh and Cornelis J. M. Melief},
  journal={European journal of immunology},
  year={1989},
  volume={19 3},
  pages={537-42}
}
Two class I major histocompatibility (MHC) mutant mouse strains, H-2bm14 and H-2bm6, differ from the strain of origin C57BL/6 (B6, H-2b) in one and two amino acids of the H-2Db and H-2Kb molecule, respectively. The bm14 Db mutation results in specific failure of female bm14 mice to generate a cytotoxic T lymphocyte (Tc) response to the male-specific antigen… CONTINUE READING