Specific immune cell and cytokine characteristics of human testicular germ cell neoplasia.

  title={Specific immune cell and cytokine characteristics of human testicular germ cell neoplasia.},
  author={Britta Klein and Thomas Haggeney and Daniela Fietz and Sivanjah Indumathy and Kate L Loveland and Mark P Hedger and Sabine Kliesch and Wolfgang Weidner and Martin W Bergmann and H Schuppe},
  journal={Human reproduction},
  volume={31 10},
STUDY QUESTION Which immune cells and cytokine profiles are characteristic for testicular germ cell neoplasia and what consequences does this have for the understanding of the related testicular immunopathology? SUMMARY ANSWER The unique immune environment of testicular germ cell neoplasia comprises B cells and dendritic cells as well as high transcript levels of IL-6 and other B cell supporting or T helper cell type 1 (Th1)-driven cytokines and thus differs profoundly from normal testis or… CONTINUE READING
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