Specific human antibodies do not inhibit Trypanosoma cruzi oligopeptidase B and cathepsin B, and immunoglobulin G enhances the activity of trypomastigote-secreted oligopeptidase B.

@article{Fernandes2005SpecificHA,
  title={Specific human antibodies do not inhibit Trypanosoma cruzi oligopeptidase B and cathepsin B, and immunoglobulin G enhances the activity of trypomastigote-secreted oligopeptidase B.},
  author={L. C. Fernandes and I. D. Bastos and L. Lauria-Pires and A. Rosa and A. Teixeira and P. Grellier and J. Schr{\'e}vel and J. Santana},
  journal={Microbes and infection},
  year={2005},
  volume={7 3},
  pages={
          375-84
        }
}
Trypanosoma cruzi expresses oligopeptidase B and cathepsin B that have important functions in the interaction with mammalian host cells. In this study, we demonstrated that sera from both chagasic rabbits and humans have specific antibodies to highly purified native oligopeptidase B and cathepsin B. Levels of antibodies to cathepsin B were higher than those observed to oligopeptidase B by absorbance values recorded upon ELISA. We next showed that 90% and 30% of sera from individuals with… Expand
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