Specific hla‐dqa and hla‐drb1 alleles confer susceptibility to sjögren's syndrome and autoantibody production

@article{Fei1991SpecificHA,
  title={Specific hla‐dqa and hla‐drb1 alleles confer susceptibility to sj{\"o}gren's syndrome and autoantibody production},
  author={H M Fei and Hoil Kang and Carol L. Peebles and Robert Irving Fox and Stephen Joel Scharf and Henry A. Erlich},
  journal={Journal of Clinical Laboratory Analysis},
  year={1991},
  volume={5}
}
Primary Sjögren's syndrome (1° SS) is a systemic autoimmune disease characterized by lymphocytic infiltration of the salivary glands and autoantibody production. In order to identify genetic factors that play a role in pathogenesis and predict extent of disease, we used Southern blot and polymerase chain reaction (PCR) methods to detect polymorphisms of the HLA‐DRB1 (DR), HLA‐DRB3 (DRw52), and HLA‐DQA1 genes among 75 Caucasoid 1° SS patients and 150 Caucasoid controls living in the same… 
TAP, HLA-DQB1, and HLA-DRB1 polymorphism in Colombian patients with primary Sjögren's syndrome.
TLDR
Genetic evidence is shown suggesting that, in Colombians, a region immersed or in the vicinity in the HLA class II system is strongly associated with a predisposition to acquire pSS, which is probably located between the TAP2 and HLA-DQB1 locus.
HLA markers and clinical characteristics in Caucasians with primary Sjögren's syndrome.
TLDR
The association of HLA Class II markers with pSS may concern the anti-Ro/La response rather than the disease itself, given the prominent associations with DRB1*03 and the complex dose dependent interactions at HLA-DQ.
Clinical, immunological, and immunogenetic aspects of autoantibody production against Ro/SSA, La/SSB and their linear epitopes in primary Sjögren's syndrome (pSS): a European multicentre study
TLDR
Autoantibodies against La/SSB, binding to four synthetic peptides, derived from the sequence of the La protein were identified with increased frequency in sera of patients with pSS, suggesting that a model of HLA restricted presentation of La/ SSB peptide determinants is crucial for the autoimmune response against La-SSB.
In primary Sjögren's syndrome, HLA class II is associated exclusively with autoantibody production and spreading of the autoimmune response.
TLDR
The absence of a difference in disease severity between groups 2 and 3, as well as the restricted association of HLA-DRB1*03 in group 3, strongly suggest that HLA alleles predispose to autoantibody secretion, without being associated with clinical outcome.
Autoantibodies in Primary Sjögren's Syndrome: New Insights into Mechanisms of Autoantibody Diversification and Disease Pathogenesis
TLDR
Anti-M3 receptor autoantibodies occur in both primary and secondary SS and allow Sjögren's syndrome to be viewed as a disorder of anti-receptor autoimmunity.
D6S439 microsatellite identifies a new susceptibility region for primary Sjögren's syndrome.
TLDR
The results indicate that D6S439 microsatellite defines a new susceptibility region for primary SS, independent of LD with TAP and HLA DQ/DR, which might imply that a gene surrounding this location is causally related to the disease.
Immunogenetics of primary Sjögren's syndrome in Colombians.
Anti-SSB/La antibody is negatively associated with HLA-DR2 in chronic hepatitis C infection
TLDR
In conclusion, anti-SSA/Ro and anti-SSB/La antibodies present frequently in HCV-infected patients and their possible associations with HLA-DRB1 polymorphism in Chinese patients in Taiwan are examined.
Section Reviews: Biologicals & Immunologicals: Sjögren's syndrome: Pathogenesis and prospects for therapy
TLDR
It is proposed that T-cells directed against self epitopes escape ‘tolerance’ in the thymus due to the relatively weak binding of a self peptide to self major histocompatibility complex molecules.
Sjögren's syndrome (SjS)-like disease of mice: the importance of B lymphocytes and autoantibodies.
TLDR
An in-depth discussion of how B cell populations may be involved in orchestrating or determining exocrine gland dysfunction is presented.
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References

SHOWING 1-10 OF 39 REFERENCES
Specific HLA-DQB and HLA-DRB1 alleles confer susceptibility to pemphigus vulgaris.
TLDR
Results obtained by using a method for allele-specific polymerase chain reaction amplification strongly support the hypothesis that the allele DQB1.3 confers susceptibility to pemphigus vulgaris.
Gene interaction at HLA-DQ enhances autoantibody production in primary Sjögren's syndrome.
TLDR
Data suggest that gene interaction between DQ1 and DQ2 (or alleles at associated loci), possibly from gene complementation of trans-associated surface molecules, influences the autoimmune response in primary Sjögren's syndrome.
HLA-D antigen frequencies in Sjögren's syndrome. Differences between the primary and secondary form.
TLDR
It is concluded that genetic factors associated with the HLA-system are involved in the development of Sjögren's syndrome and that these genetic factors are different in primary and secondary Sj Ögren’s syndrome.
HLA DR alloantigens in different subsets of patients with Sjögren's syndrome and in family members.
TLDR
Three families with multiple individuals with Sjogren's syndrome were typed for HLA antigens, suggesting the possibility of haplotype interaction in predisposition to disease.
An extended HLA-D region haplotype associated with celiac disease.
TLDR
Within the celiac-disease patient population, the joint segregation of these HLA-DP genes with those encoding the serologic specificities Hla-DR3 and -DQw2 indicates that the class II HLA haplotype associated with celiac disease is extended throughout the entire HLA -D region.
Expression of a cross-reactive idiotype on rheumatoid factor in patients with Sjogren's syndrome.
TLDR
It is demonstrated that RF from 12/15 SS patients contains a cross-reactive idiotype (CRI) on their kappa light chain defined by a monoclonal antibody (MoAb 17-109) and immunoblotting.
Association of HLA-DR3 with human immune response to Lol p I and Lol p II allergens in allergic subjects.
TLDR
The authors' data, along with recent RFLP and DNA sequence studies, suggest that an Ia molecule involved in immune recognition of a similar major Ia recognition site of both the Lol molecules may consist of a DR3 alpha-beta I pair.
Linkage of HLA-DR beta specific restriction fragment length polymorphisms with Graves' disease.
TLDR
HLA-DR3 positive patients with Graves' disease were studied by restriction fragment length polymorphism analysis using TaqI as restriction enzyme to provide evidence that a DNA polymorphism of the HLA-DR beta genes, which is also reflected at the product level, is linked to Graves' Disease.
Antibodies to SS-B in chronic inflammatory connective tissue diseases. Relationship with HLA-Dw2 and HLA-Dw3 antigens in primary Sjögren's syndrome.
TLDR
These antigens or specific immune-response genes close to the D region may be important for the development of antibodies to SS-B in patients with well-defined and characterized chronic inflammatory connective tissue disease.
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